Instant Karma centers on overachiever Prudence Barnett who is known to quickly cast judgment on others. After dreaming of being able to inflict karma on the frustrating residents of her coastal town, Prudence is surprised when she wakes up with the sudden ability to cast instant karma on those around her. However, there's one person powers backfire on, her lazy lab partner Quint. After volunteering at the rescue center where Quint works, Prudence begins to not only learn more about Quint but begins questioning her initial judgments of everyone around her.