Best of the West is a spoof that featured the misadventures of Sam Best, a Civil War veteran who becomes a marshal in Copper Creek after accidentally scaring off an incompetent gunfighter called the Calico Kid. Sam's family was made up of his Southern-belle wife Elvira and his smart-mouthed son Daniel. The cast also included villain Parker Tillman, drunken town doctor Jerome Kullens, and Tillman's clueless but kind-hearted henchman, Frog Rothchild, Jr.