As they travel towards Cyllage City, Team Rocket encounter a new adversary in Madame X and her partner Pokémon, Malamar. Madame X had managed to use her powers to brainwash Jessie and James into doing her bidding before Meowth managed to escape. However, without any allies in this region, Meowth must turn to Ash & Co. for help. However, one by one, everyone starts to get brainwashed, including Pikachu. What will Ash do? Will he and Meowth manage to stop Madame X?