Two best friends and comic book fanboys, Kaz and Oliver, discover a doorway leading to top-secret hospital called "Mighty Med," where they realize that all their favorite superheroes are real! There, they meet Skylar Storm, a teen hero who recently lost her powers, Horace Diaz, the hospital's Chief of Staff, and Alan Diaz, Horace's meddling nephew with telekinesis powers. When Kaz's all-time favorite superhero Tecton is rushed into the hospital, the boys must use their comic books knowledge to find a way to save Tecton before his nemesis Megahertz finds him first.