After going it alone in connection with his arch-enemy Firat Astan's attempt to break out, the murder of his ex-wife Isabella Schoppenroth and a sensational hostage-taking, LKA investigator Nick Tschiller was suspended for a while. He wants to use the time to finally take care of his daughter Lenny more as a single father. But then it disappears. Tschiller's loyal partner Yalcin Gümer can locate Lenny's cell phone in Istanbul. The girl probably wants to avenge her mother on her own in Turkey. When Nick learns that his nemesis also managed to escape from Turkish prison, he knows that his daughter is in danger. So he has to do what he does best again: take up arms.
When he learns in Istanbul that his daughter has fallen into the clutches of Russian gangsters and that shady organ dealers have taken her to Moscow, where they want to "cannibalize" Lenny, a race against time finally begins for Nick.