"Extreme Makeover: Home Edition" travels to Pine Mountain Valley, GA, to meet Jeremy and Jennifer Williams, whose son, Jacob, was diagnosed with Spina Bifida before he was born. Then, several years after Jacob's birth, Jeremy was diagnosed with Lou Gehrig's disease. Now the home Jeremy and Jennifer bought 13 years ago is falling apart around them. In addition to mounting repairs, the home is too small to accommodate two disabled family members. NFL Star Michael Oher and the Tuohy Family ("The Blind Side") are the "Get on the Bus" volunteers, while ESPN football analysts Herm Edwards, Mark Schlereth, Mark May and Desmond Howard are special guests. Plus, Demi Lovato and Wilmer Valderrama also appear in the episode.