Poof becomes sick with Chicken Poofs, an infectious fairy disease that turns him into a chicken and turns other people into chickens when he sneezes on them. Although Dr. Rip Studwell has the cure, Poof, afraid of the needle, runs away. Timmy and Cosmo must catch him and cure his illness before the whole of Dimmsdale is turned into chickens. Meanwhile, Dr. Rip Studwell and Wanda search a Fairy World temple for more medicine since all of it has been accidentally dropped.