Narcotics smuggler Dino Patrone returns to the United States after visiting the old country for several months. He brings his younger sister Carla with him as she plans on studying in the U.S. Little does Dino know that his boss Victor Bardo has ordered his best friend Willie Asher to kill him. Traveling on the train to Chicago, Dino meets an acquaintance, print and radio journalist Loren Hall. Dino soon meets his end and it falls to Hall, who reluctantly agrees to work with Eliot Ness, to help Carla Patrone after she is kidnapped by the mobsters.