The Gaines Twins, Roxanne and Roland, a brother and sister pair with uncanny mental powers, being transported in an armored convoy when a well planned traffic accident allows them to escape. Well, almost. That is until Spider-Man appears on the scene and battles the twins' mental abilities and overcomes their brain-blasts with his own superhuman willpower. Later that afternoon Peter Parker learns that Pterodax, the crime trio comprised of former KGB agents led by Sergei, has just sprung Silver Sable from prison. Spider-Man's enemies seem to be popping up all over! Silver Sable allies with Kraven the Hunter who has recently escaped from jail as well in order to seek out revenge on Spider-Man. Spider-Man runs into Mary-Jane Watson and delivers some surprising news. Meanwhile, Kraven has murder on his mind and if he can't find Spider-Man it looks like he'll settle for MJ. To make things even more uncanny, a mysterious stranger Frank Elson has approached Peter Parker to give him vital information to help the webslinger out - or does Frank have his own agenda. Is anything as it seems? What exactly is going on? Is MJ really dead, did Spider-Man reveal himself as Peter Parker? Or is it all in Spider-Man's head?