Jay Burchell, Tyler Fog and Will Traveler -- friends who have spent virtually every minute of the last two years living, working and partying together as grad-school students -- set off on a road trip to New York. Once there, the three enter New York's oldest art museum for an innocent prank: Jay and Tyler lace up their rollerblades inside and speed off to see who can make it out of the building first. When they're both outside, Will calls on his cell phone saying, "Sorry, I had to do this" -- and then the building blows up! Now, with Jay and Tyler's rollerblading prank on the museum's security tapes, blame for the attack focuses on them; they in turn realize that their "friend," Will, may have set them up. Unable to find him or indeed any evidence that the Will Traveler they knew even existed, Jay and Tyler flee the city and go on the run.