Paramedics are called to a custody suite in Birmingham to deal with a prisoner who is aggressive and abusive but may have overdosed on heroin. Paramedic Rob Moore and student paramedic Ally Shipway tread a fine line between looking after him and themselves. At the same time, across the city, paramedics Jo Hardwick and Peter Bowles are called to a man who is found unconscious at the roadside, but when they wake him his mood dramatically changes and they need to decide on the best care for him. A man is cut out of his car after crashing into another vehicle, and paramedics struggle to find a patient who hung up halfway through their 999 call.