When her father Ludo ends up in hospital after a serious hunting accident, Isabelle returns to the Netherlands with her son Art, after having lived in America for years. Ludo asks Isabelle to take over the role of CEO in the family business, Rombauts Pharmaceuticals. This displeases her brother Julien, who has been working for the company for years and has big plans for the company in China. The statements that Isabelle makes in her new role at a talk show table are not appreciated by everyone. In the meantime, Art gets to know Lola. He is immediately impressed by her.